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Monitor all patients taking ZOLOFT for the emergence of serotonin syndromeDiscontinue treatment with ZOLOFT and any concomitant serotonergic agents immediately if the above symptoms occurand initiate supportive symptomatic treatmentIf concomitant use of ZOLOFT with other serotonergic drugs is clinically warrantedinform patients of the increased risk for serotonin syndrome and monitor for symptoms.

Efficacy was assessed with the Daily Record of Severity of ProblemsDRSPa patient-rated instrument that mirrors the diagnostic criteria for PMDD as identified in the DSM-IVand includes assessments for moodphysical symptomsand other symptomsOther efficacy assessments included the Hamilton Rating Scale for DepressionHAMD-17and the Clinical Global Impression Severity of IllnessCGI-Sand ImprovementCGI-Iscores.

Inform patients about the concomitant use of ZOLOFT with aspirinNSAIDsother antiplatelet drugswarfarinor other anticoagulants because the combined use has been associated with an increased risk of bleedingAdvise patients to inform their health care providers if they are taking or planning to take any prescription or over-thecounter medications that increase the risk of bleedingSee WARNINGS AND PRECAUTIONS

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based on my experience, while zoloft can keep you from getting majorly depressed, it also has the unfortunate tendency of preventing you from feeling genuine happiness or joy.


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