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In patients with moderate renal impairment baseline creatinine clearance 30 to 50 ml min , a dose reduction to 75 of the xeloda starting dose when used as monotherapy or in combination with docetaxel from 1250 mg m 2 to 950 mg m 2 twice daily is recommended see use in specific populations and clinical pharmacology .

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In both trialsoverall survivaltime to progression and response ratecomplete plus partial responseswere assessedResponses were defined by the World Health Organization criteria and submitted to a blinded independent review committeeIRCDifferences in assessments between the investigator and IRC were reconciled by the sponsorblinded to treatment armaccording to a specified algorithmSurvival was assessed based on a non-inferiority analysis.

Figure 5 Kaplan-Meier Estimates of Survival XELODA and Docetaxel vs Docetaxel.

Find out what capecitabine ishow you have it and other important information about having capecitabine.

Diarrhea nausea vomiting mouth and throat sores loss of appetite or decreased appetite excessive water loss from the bodydehydrationhand-foot syndrome irregular periods this can include temporary cessationusually resume after medication is completedor permanent cessation of menstrual periods depending on your age and other factors.

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