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Lioresal has been shown to increase the incidence of omphaloceles ventral hernias in fetuses of rats given approximately 13 times the maximum dose recommended for human use, at a dose which caused significant reductions in food intake and weight gain in dams.

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In patients with epilepsythe clinical state and electroencephalogram should be monitored at regular intervalssince deterioration in seizure control and EEG have been reported occasionally in patients taking Lioresal.

Abrupt discontinuation of intrathecal baclofenregardless of the causehas resulted in sequelae that include high feveraltered mental statusexaggerated rebound spasticityand muscle rigiditythat in rare cases has advanced to rhabdomyolysismultiple organ-system failure and death.

Tell your doctor or pharmacist if you are taking other products that cause drowsiness such as opioid pain or cough relieverssuch as codeinehydrocodonealcoholmarijuanadrugs for sleep or anxietysuch as alprazolamlorazepamzolpidemother muscle relaxantssuch as carisoprodolcyclobenzaprineor antihistaminessuch as cetirizinediphenhydramine

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