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Short-term less than or equal to 4 days coadministration of aspirin with pletal increased the inhibition of arachidonic acid-induced ex vivo platelet aggregation by 20 compared to pletal alone and by 48 compared to aspirin alone.

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Cases of thrombocytopenia or leukopenia progressing to agranulocytosis when Pletal was not immediately discontinued have been reportedAgranulocytosis is reversible on discontinuation of PletalMonitor platelets and white blood cell counts periodically.

Patients may respond as early as 2 to 4 weeks after the initiation of therapybut treatment for up to 12 weeks may be needed before a beneficial effect is experiencedIf symptoms are unimproved after 3 monthsdiscontinue PLETAL.

Cilostazol did not inhibit the pharmacologic effectsPTaPTTbleeding timeor platelet aggregationof Rand S-warfarin after a single 25-mg dose of warfarinThe effect of concomitant multiple dosing of warfarin and Pletal on the pharmacodynamics of both drugs is unknown.

Read this Patient Information leaflet before you start taking Pletal and each time you get a refillThere may be new informationThis information does not take the place of talking to your doctor about your medical condition or your treatment.

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