The rcps for each drug are listed below recognized drug name dosages claim percentage kytril injection granisetron gsk injection 1mg ml 50 hcl ; category a injection 2mg ml drugs zofran injection ondansetron injection pre-mixed ; 50 hcl ; 32mg 50ml; 4mg gsk category b drugs alkeran melphalan ; imitrex sumatriptan ; kytril tablets granisetron hcl ; lanoxin digoxin ; myleran busulfan ; navelbine vinorelbine tartrate ; retrovir zidovudine ; ventolin albuterol ; zofran orals ondansetron hcl ; zovirax acyclovir ; zantac ranitidine hcl ; injection 50mg tablets 2mg injection 12mg 1ml 6mg ; tablets 1mg injection 0.
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The most common adverse reactions reported in 4 trials in adults for the prevention of nausea and vomiting associated with moderately emetogenic chemotherapyprimarily cyclophosphamide-based regimensare shown in Table 3.
HepaticAspartate transaminaseASTand/or alanine transaminaseALTvalues exceeded twice the upper limit of normal in approximately 1to 2of 723 patients receiving ZOFRAN and cyclophosphamide-based chemotherapy in US clinical trialsThe increases were transient and did not appear to be related to dose or duration of therapyOn repeat exposuresimilar transient elevations in transaminase values occurred in some coursesbut symptomatic hepatic disease did not occurThe role of cancer chemotherapy in these biochemical changes is unclear.
Otherless than 2Anaphylaxisbronchospasmtachycardiaanginahypokalemiaelectrocardiographic alterationsvascular occlusive eventsand grand mal seizuresExcept for bronchospasm and anaphylaxisthe relationship to ZOFRAN is unclear.
Carmustineetoposideand cisplatin do not affect the pharmacokinetics of ondansetron.
What should I discuss with my health care provider before taking ondansetronZofranZofran ODTZuplenz
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1992 shortly after zofran hit the market, adverse event reports were received that suggested a potential risk of birth defects with zofran use.