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In neonatal/juvenile animalsrats and dogstoxicities were similar to those observed in adult animalsincluding gastric alterationsdecreases in red cell massincreases in lipidsenzyme induction and hepatocellular hypertrophyAn increased incidence of eosinophilic chief cells in adult and neonatal/juvenile ratsand atrophy of chief cells in adult rats and in neonatal/juvenile dogswas observed in the fundic mucosa of stomachs in repeated-dose studiesFull to partial recovery of these effects were noted in animals of both age groups following a recovery period.
The reconstituted solution may be stored for up to 24 hours at room temperature prior to intravenous infusion and does not need to be protected from light.
There are no data available on the effects of intravenous pantoprazole sodium on ECL cells.
The following serious adverse reactions are described below and elsewhere in labeling:
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if you have trouble swallowing a protonix 40 mg tablet, you can take two 20 mg tablets instead.