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COUMADIN is contraindicated in women who are pregnant except in pregnant women with mechanical heart valveswho are at high risk of thromboembolismsee WARNINGS AND PRECAUTIONS and Use In Specific PopulationsCOUMADIN can cause fetal harm when administered to a pregnant womanCOUMADIN exposure during pregnancy causes a recognized pattern of major congenital malformationswarfarin embryopathy and fetotoxicityfatal fetal hemorrhageand an increased risk of spontaneous abortion and fetal mortalityIf COUMADIN is used during pregnancy or if the patient becomes pregnant while taking this drugthe patient should be apprised of the potential hazard to a fetussee Use In Specific Populations

Talk with your doctor if you are planning any major dietary changessuch as following a weight-reducing diet or adding nutritional supplements.

The prothrombin timePT or protimetest will tell your doctor how fast your blood is clotting and whether your dose needs to be changedIllnessdietchanges to your medicinesand physical activities may affect the results.

If you cut yourself and it’s largeapply constant pressure and get help immediatelyeither by phone or at the emergency roomCall your doctor if you have any symptoms of illness like vomitingdiarrheainfectionor feverIllness can change the way warfarin works.

There were approximately four times as many major bleeding episodes in the two groups receiving warfarin than in the group receiving aspirin aloneMajor bleeding episodes were not more frequent among patients receiving aspirin plus warfarin than among those receiving warfarin alonebut the incidence of minor bleeding episodes was higher in the combined therapy group.

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these conditions can occur without warning while you are taking aspirin and caffeine, especially if you are age 60 or older; if you have a stomach ulcer or a history of stomach or intestinal bleeding; if take a blood thinner warfarin, coumadin or steroid medicine; if you drink more than 3 alcoholic beverages per day; or if you take the medicine for longer than recommended.


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