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Gemfibrozil can increase the effect of the blood thinnerwarfarinCoumadinand thus may lead to bleedingThereforepatients on warfarin may need to have their doses of warfarin reduced when starting gemfibrozil.

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LovastatinMevacorpravastatinPravacholsimvastatinZocorfluvastatinLescolrosuvastatinCrestorand atorvastatinLipitorAll these increase the risk of a condition called rhabdomyolysismuscle injurythat when severe can lead to kidney damage and even deathRhabdomyolysis may occur as early as three weeks or several months after starting combination therapyThe benefit of combining gemfibrozil with statins does not outweigh the risk of rhabdomyolysis.

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ticlopidina e clopidogrel trattamento concomitante con questi farmaci possono aumentare l esposizione bupropione, ma ridurre l esposizione idrossibupropione.

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