Minocycline hydrochloride, usp, is a semisynthetic derivative of tetracycline, 4,7-bis dimethylamino -1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride.
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The hue and severity of tooth discoloration depend on four factors associated with tetracycline administration:
Antibiotic medicines can cause diarrheawhich may be a sign of a new infectionIf you have diarrhea that is watery or has blood in itcall your doctorDo not use any medicine to stop the diarrhea unless your doctor has told you to.
Principles of Drug TherapyDosingand Prescribing in Chronic Kidney Disease and Renal Replacement Therapy.
Doxycycline is usually preferred for all of the following because it is better tolerated and can be given twice/day:
Tetracyclines are well absorbed after oral administration and are probably active against parasite protein synthesisSide effects include gastrointestinal distressphotosensitivity and vaginal candidiasis.
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to reduce the risk of esophageal irritation and ulceration, tetracycline capsules or tablets should be administered with adequate amounts of fluid and probably should not be given at bedtime or to patients with esophageal obstruction or compression.