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CUse with caution if benefits outweigh risksAnimal studies show risk and human studies not available or neither animal nor human studies done.

Patients should be monitored closely for changes in behaviorclinical worseningand suicidal tendenciesthis should be done during the initial 1-2 months of therapy and dosage adjustments.

Swallow the extended-release and regular tablets wholedo not chew or crush them.

DurationMajor Depressive DisorderAcute episodes require several months or longer of sustained pharmacologic therapysystemic evaluation has shown that efficacy was maintained for up to one yearPanic DisorderEfficacy has been demonstrated for up to 12 weeksbeing a chronic conditioncontinuation of treatment may be considered in responding patients.

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