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PRECAUTIONSBefore taking granisetrontell your doctor or pharmacist if you are allergic to itor if you have any other allergiesThis product may contain inactive ingredientswhich can cause allergic reactions or other problemsTalk to your pharmacist for more details.Before using this medicationtell your doctor or pharmacist your medical history.This drug may make you dizzy or drowsyDo not driveuse machineryor do any activity that requires alertness until you are sure you can perform such activities safelyLimit alcoholic beverages.Granisetron may cause a condition that affects the heart rhythmQT prolongationQT prolongation can infrequently result in seriousrarely fatalfast/irregular heartbeat and other symptomssuch as severe dizzinessfaintingthat need medical attention right away.The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongationBefore using granisetrontell your doctor or pharmacist of all the drugs you take and if you have any of the following conditionscertain heart problemsheart failureslow heartbeatQT prolongation in the EKGfamily history of certain heart problemsQT prolongation in the EKGsudden cardiac deathLow levels of potassium or magnesium in the blood may also increase your risk of QT prolongationThis risk may increase if you use certain drugssuch as diureticswater pillsor if you have conditions such as severe sweatingdiarrheaor vomitingTalk to your doctor about using granisetron safely.Older adults may be more sensitive to the side effects of this drugespecially QT prolongationsee aboveThis medication should be used only when clearly needed during pregnancyDiscuss the risks and benefits with your doctor.It is not known whether this drug passes into breast milkConsult your doctor before breast-feeding.

The amended information to doctors and patients is available under theall documentstab.

Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongationThis risk may increase if you use certain drugssuch as diureticswater pillsor if you have conditions such as severe sweatingdiarrheaor vomitingTalk to your doctor about using granisetron safely.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effectsMany people using this medication do not have serious side effects.

In healthy volunteers and adult cancer patients undergoing chemotherapyadministration of KYTRILgranisetronTablets produced mean pharmacokinetic data shown in Table 1.

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